I can't claim to be very familiar with Sentinels as I have never seen the series but it would be very fitting from what I heard.

and Amanda as Irene would be a sublime move! Leaving Holmes cuffed to a bed is very much an Amanda move, though i can't see her being so manipulated by Moriaty and I confess that I really wanted to include the ROG somewhere, maybe as Mycroft's friend although he doesn't show up on this movie and never seemed like someone who would have friends.

Mrs.Hudson though always seems to be more than what she really is, or at least know more than it seems and she is always overlooked